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Volume 1
Main Index

Issue 1


Hypotensive Hydrazinophthalazines and Related Compounds
J. Druey and A. Marxer
pp 1 - 21; DOI:
10.1021/jm50002a001
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A New Class of Antispasmodies with Considerable Activity
N P. Buu-Hoï, Richard Rips, and R. Cavier
pp 23 - 30; DOI:
10.1021/jm50002a002
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5-Ethyl-5-(1,3-Dimethyi-2-Butenyl)Barbituric Acid, A Potent Central Nervous System Stimulant
C. K. Cain and John Kleis
pp 31 - 36; DOI:
10.1021/jm50002a003
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Alpha- and Beta-Prodine Type Compounds
A. H. Beckett, A. F. Casy, and G. Kirk
pp 37 - 58; DOI:
10.1021/jm50002a004
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Pharmacology of two Tetracovalent Organophosphorus Compounds and their Optical Isomers
Duane G. Wenzel and George N. Beckloff
pp 59 - 71; DOI:
10.1021/jm50002a005
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Derivatives of 3-Pyrrolidinols--I. The Chemistry, Pharmacology and Toxicology if Some N-Substituted-3-benzhydryloxypyrrolidines
Carl D. Lunsford, John W. Ward, Arthur J. Pallotta, T. W. Tusing, Edward K. Rose, and Robert S. Murphey
pp 73 - 94; DOI:
10.1021/jm50002a006
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A Chemical and Pharmacological Investigation of Piper Methysticum Forst
M. W. Klohs, F. Keller, R. E. Williams, M. I. Toekes, and G. E. Cronheim
pp 95 - 103; DOI:
10.1021/jm50002a007
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Compounds Related to Pethidine--I. Mannich Bases Derived from Norpethidine and Acetophenones
Paul A. J. Janssen, Anton H. M. Jageneau, Paul J. A. Demoen, Corn. van De. Westeringh, Alfons H. M. Raeymaekers, Maria S. J. Wouters, Stefan Sanczuk, Bert K. F. Hermans, and Jozef L. M. Loomans
pp 105 - 120; DOI:
10.1021/jm50002a008
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Issue 2


The Trifluoromethyl Group in Medical Chemistry
Harry L. Yale
pp 121 - 133; DOI:
10.1021/jm50003a001
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The Reactions of Nitrofurans with Bacteria--II. Reduction of a Series of Antibacterial Nitrofurans by Aerobactor aerogenes
A. H. Beckett and Ann E. Robinson
pp 135 - 154; DOI:
10.1021/jm50003a002
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The Reaction of Nitrofurans with Bacteria--III. Reduction of a Series of Antibacterial Nitrofurans (Type B Compounds) by Aerobacter aerogenes
A. H. Beckett and Ann E. Robinson
pp 155 - 164; DOI:
10.1021/jm50003a003
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Synthesis and Biological Activity of Some N-(Substituted) Glutamines
Jerome Edelson, Charles G. Skinner, and William Shive
pp 165 - 170; DOI:
10.1021/jm50003a004
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Synthsis and Radioprotective Properties of Chlorinated O-Dialkylaminopropionamido- and O-Dialkylaminopropylaminodiphenyl Sulphide Derivatives
Alfred Burger, James G. Beasley, Richard B. Margerison, John Doull, Vivian Plzak, and John F. Noble
pp 171 - 179; DOI:
10.1021/jm50003a005
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Flurocompounds Related to the Reversed Esters of Pethidine
N. J. Harper and A. B. Simmonds
pp 181 - 185; DOI:
10.1021/jm50003a006
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The Influence of Heterocyclic Ring Size of Tertiary 2,2-Diphenyl-4amino-butyramides on Parasympatholytic Activity
Paul A. J. Janssen, Paul J. A. Demoen, Anton H. M. Jageneau, and Jos L. M. Loomans
pp 187 - 194; DOI:
10.1021/jm50003a007
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Book Reviews
Alfred Burger
pp 195 - 196; DOI:
10.1021/jm50003a008
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Issue 3


Potential Chemotherapeutic Compounds--III. Derivatives of 2-Aminodiphenylamine and N,N-Bis(4-aminophenyl)-alkylamines
Milton C. Kloetzel, Stanley J. Davis, Upendra Pandit, C. Richard Smith, and Hisako Nishihara
pp 197 - 211; DOI:
10.1021/jm50004a001
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Vitamin B6--Phosphonic Acids
Raymond Bennett, Alfred Burger, and W. W. Umbreit
pp 213 - 221; DOI:
10.1021/jm50004a002
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Structure-Activity Relationship of Some Diamine Bis-epoxides in Mouse Leukaemia
Koert Gerzon, James E. Cochran, Lawrence A. White, Rosmarie Monahan, Eriks V. Krumkalns, Robert E. Scroggs, and Jack Mills
pp 223 - 243; DOI:
10.1021/jm50004a003
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A Study of the Interactions of Folic Acid Analogues and 6-(Substituted)Purines as Growth Inhibitors
Edwin M. Lansford and William Shive
pp 245 - 262; DOI:
10.1021/jm50004a004
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Spectrophotometric Method for the Determination of Chlorpromazine and Chlorpromazine Sulphoxide in Biological Fluids
T. L. Flanagan, T. H. Lin, W. J. Novick, I. M. Rondish, C. A. Bocher, and E. J. Van Loon
pp 263 - 273; DOI:
10.1021/jm50004a005
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Decreased Gastric Secretory Activity following Injection of Certain Maleimides, β-Mercaptoethylamine (or AET), or the combination of both types
T. Lloyd Fletcher, Helene L. Buchman, Allen W. Dahl, John E. Jesseph, Henry N. Harkins, and Ruth Helen Larsen
pp 275 - 280; DOI:
10.1021/jm50004a006
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Chemistry and Pharmacology of CNS Depressants Related to 4-(4-Hydroxy-4-phenylpiperidino)butyrophenone Part I--Synthesis and screening data in mice
Paul A. J. Janssen, Corn. Van De Westeringh, Anton H. M. Jageneau, Paul J. A. Demoen, Bert K. F. Hermans, Georges H. P. Van Daele, Karel H. L. Schellekens, Cyriel A. M. Van Der Eycken, and Carlos J. E. Niemegeers
pp 281 - 297; DOI:
10.1021/jm50004a007
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Book Review
Alfred Burger
pp 298 - 298; DOI:
10.1021/jm50004a008
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Issue 4


Synthesis Anti-diarrhoeal Agents--I. Some Pharmacological Properties of R 1132 and Related Compounds
Edwin M. Lansford, Paul A. J. Janssen, Anton H. Jageneau, and Jules Huygens
pp 299 - 308; DOI:
10.1021/jm50005a001
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Compounds Related to Pethidine--II. Mannich Bases Derived from Various Esters of 4-Carboxy-4-phenylpiperidine and Acetophenones
Paul A. J. Janssen, Anton H. M. Jageneau, Paul J. A. Demoen, Corn. van De Westeringh, Julienne H. M. De Canniere, Alfons H. M. Raeymaekers, Maria S. J. Wouters, Stefan Sanczuk, and Bert K. F. Hermans
pp 309 - 317; DOI:
10.1021/jm50005a002
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Relationship between Constitution and Activity in a Series of 2,5-Disubstitute 1-(2-Dialkylaminoalkoxyphenyl) Pyrroles
N. P. Buu-Hoï, Richard Rips, and R. Cavier
pp 319 - 325; DOI:
10.1021/jm50005a003
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Mechanism of Drug Action at Receptor Surfaces--II. Chemical Reactivity of N-(β-chloroethyl)-Phenoxyethylamines in Relation to Adrenergic Blocking Activity
B. Belleau
pp 327 - 342; DOI:
10.1021/jm50005a004
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Mechanism of Drug Action at Receptor Surfaces--III. Chemical Reactivity and Conformation of Spiro-Ethylenimmonium Ions in Relation to Adrenergic Blocking Activity
B. Belleau
pp 343 - 354; DOI:
10.1021/jm50005a005
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Anaesthetic Action and Toxicity of Oxetanes in White Rats
H. T. Gier and Scott Searles
pp 355 - 363; DOI:
10.1021/jm50005a006
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The Concept of a Supporting Moiety as Applied to the Synthesis of Anti-viral Compounds
G. Cavallini and E. Massarani
pp 365 - 370; DOI:
10.1021/jm50005a007
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Synthesis of Possible Antimetabolites in the Purine Series
Hayim Segal and David Shapiro
pp 371 - 380; DOI:
10.1021/jm50005a008
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Hydroxylamine Analogues Pheniramine
Randolph T. Major, Hans-Jurgen Hess, and Clement A. Stone
pp 381 - 390; DOI:
10.1021/jm50005a009
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Structure-Activity Relationship in BHC Stereoisomers
Alexander Gero
pp 391 - 394; DOI:
10.1021/jm50005a010
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Issue 5


Chemistry and Structure-Activity Relationships of Amphenone Analogues
W. L. Bencze and M. J. Allen
pp 395 - 406; DOI:
10.1021/jm50006a001
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Pharmacology and Biochemistry of Some Amphenone Analogues and other Adrenal Cortical Inhibitors
J. J. Chart and H. Sheppard
pp 407 - 441; DOI:
10.1021/jm50006a002
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Emylcamate, A Potent Tranquillizing Relaxant
B. Melander
pp 443 - 457; DOI:
10.1021/jm50006a003
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Comparative Ganglion-blocking Potencies of the Geometric Isomers of Two Cyclic 1,2-Amino Alcohols
Frank G. Standaert, Seymour L. Friess, and Roger O. Doty
pp 459 - 466; DOI:
10.1021/jm50006a004
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Drug Latentiation
N. J. Harper
pp 467 - 500; DOI:
10.1021/jm50006a005
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Synthesis of Diethylaminoethyl Esters of p-Carboxyphenylphenylcarbinols
S. Wawzonek and C. E. Morreal
pp 501 - 504; DOI:
10.1021/jm50006a006
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Book Review
Alfred Burger
pp 505 - 505; DOI:
10.1021/jm50006a007
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Issue 6


Biological Activity in Compounds Possessing Thiophen Rings
M. Martin-Smith and S. T. Reid
pp 507 - 564; DOI:
10.1021/jm50007a001
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Heterocyclic Disulphonamides and Their Diuretic Properties
George DeStevens, Angela Halamandaris, S. Ricca, and L. H. Werner
pp 565 - 576; DOI:
10.1021/jm50007a002
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Some Heterocyclic Aldehyde Thiosemicarbazones Possing Anti-viral Activity
E. Campaigne, R. L. Thompson, and J. E. Van Werth
pp 577 - 599; DOI:
10.1021/jm50007a003
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New Anti-viral Compounds with Considerable Activity in vivo--I. Biphenyl Derivatives
G. Cavallini, E. Massarani, D. Nardi, F. Magrassi, P. Altucci, G. Lorenzutti, and U. Sapio
pp 601 - 608; DOI:
10.1021/jm50007a004
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